Quote from Jeremy Charette on April 11, 2023, 11:26 am

Genome Tech Dev Working Group – April 10, 2023

GenTechWG Recording
Passcode: 041023GenTechWG

Agenda:

• New Grantee introductions
• Topic of interest – White House Report: Bold Goals for US Biotechnology and Biomanufacturing 
• AGTD
• Genome Technology Development Series
• Post-AGTD Working Group meetings planning
• PI recommended papers

New Grantees

Judd Rice – University of Southern California
Advancing an Innovative NGS Approach to Discover and Investigate Histone Tail Proteolysis
Jef Boeke – New York University School of Medicine
The Assemblatron
Shenglong Zheng – New York Institute of Technology
Development of Next-Generation Mass Spectrometry-based de novo RNA Sequencing for all Modifications
Christopher Warren and Mary Ozers – Proteovista, LLC
Development of GenomeBuild as a Universal Method to Synthesize Genomes
Eric Ervin – Electronic Biosciences, Inc.
Sequencing the Mono-Methylated Derivatives of Cytidine
Thomas Norman – Memorial Sloan-Kettering Cancer Center
Scalable, quantitative, single-cell CRISPR screens
Lin Chen – University of Southern California
Bi-functional photo-crosslinking (BFPX) for genome-wide study of protein-nucleic acid interactions
Stirling Churchman - Harvard Medical School
Mechanisms of Transcriptional Control Revealed by Nascent Transcript Sequencing
Gudrun Stengel – Alida Biosciences, Inc.
Multiplexed Analysis of the Epitranscriptome
Prashant Mali and Trey Ideker – University of California, San Diego
Next generation massively multiplexed combinatorial genetic screens
Xin Jin – Scripps Research Institute
In vivo Perturb-map: scalable genetic screens with single-cell and spatial resolution in intact tissues.

Topic of Interest

White House Report: Bold Goals for US Biotechnology and Biomanufacturing 

AGTD

• Registration is OPEN
• April 6 – abstract submission deadline for speaking slots (submit via email to TDCC@jax.org)
• April 21 – Preliminary schedule done; notify speakers (and poster-onlys)
• May 5 – Deadline to register for in-person attendance
  • Hilton Torrey Pines Room Block:
  • Limited rooms at $186/night, then $229
  • Hotel information HERE
• May 5 – Abstract deadline (for all poster presentations)
• May 19 – Final schedule; distribute agenda
• June 6-8 – AGTD at SCRM/UC-San Diego

Genome Technology Development Series - May 17, 19, 23, 25
Downloadable material HERE that you can use to help us advertise the event

TDCC Working Group Priorities Poll

PI-recommended Top Papers Discussion

Time-tagged ticker tapes for intracellular recordings 

Recording of cellular physiological histories along optically readable self-assembling protein chains

High-precision estimation of emitter positions using Bayesian grouping of localizations

Precise genome editing across kingdoms of life using retron-derived DNA 

Continuous Multiplexed Phage Genome Editing Using Recombitrons

Programming multicellular assembly with synthetic cell adhesion molecules

Programmable protein delivery with a bacterial contractile injection system

Spatial epigenome–transcriptome co-profiling of mammalian tissues

Language models of protein sequences at the scale of evolution enable accurate structure prediction

A high-level programming language for generative protein design

Seq2MSA: A language model for protein seuqence diversification

Sequence-dependent surface condensation of a pioneer transcription factor on DNA

OpenCell: Endogenous tagging for the cartography of human cellular organization 

Exaggerated false positives by popular differential expression methods when analyzing human population samples

Clipper: p-value-free FDR control on high-throughput data from two conditions